Two months later.

  Chen Chen stood quietly in the laboratory, his face a little pale.

  Before him, a little white mouse is constantly swimming in an orris water maze.

  This little white mouse swims extremely flexibly. Although it looks a bit confused, it can always find the right way quickly after wrong attempts, and finally find a platform hidden underwater.

  No one can see that these mice had signs of serious nerve damage two weeks ago.

  Looking at the No.5 experimental mouse coming to the platform, Chen Chen gently pressed the timer and said blankly, "28 seconds, 2 seconds faster than yesterday."

  Afterwards, Chen Chen began to fill in the experimental record:

  "6-month-old genetically modified model mice were treated with surgical transplantation of cloned neural stem cells, and at the same time they were treated with myeloid trigger receptor 2 (tre2) agonist interleukin 4 (il-4) to induce microglia activation."

  "Immunohistochemistry, Western blotting, and fluorescent quantitative PCR are used to detect the expression of tre2 from the protein and gene levels."

  "The water maze experiment showed that model mice showed cognitive function recovery in the water maze experiment."

  "In this model, after il-4 treatment, the expression of tre2 increased, and the memory and cognitive impairment of model mice was greatly improved."

  "Result: The activation of tre2 may promote the reduction of autophagy of microglia through inflammation."

   Then Chen Chen bent down and caught the mouse resting on the platform, dried it and fixed it on the CT machine, and fixed the brain to a state where it could not rotate.

  Next, Chen Chen started the machine, and the CT machine began to scan the brain structure of No. 5.

  Comparing the new ct with the previous picture, I saw on the picture that the brain structure of the mouse is much fuller than last week, and it has undergone huge changes compared to two weeks ago.

  If the mouse’s brain was like a dried walnut two weeks ago, now it has become a lot fuller, just like an expanded dough.

   Randomly sorted all these data into corresponding categories. Chen Chen looked at the remaining mice in the experimental cage with the same behavior, and then he covered the experimental cage.

   Then, Chen Chen turned around and held the head of No.5 mouse, while pinching the tail root of the mouse with his right hand, and gently pulling it.

   Click it!

   A clear click came, and No. 5 in his hand died in a rapid and effective cervical dislocation.

  Chen Chen put the mouse on the dissection table and began to dissect its brain.

   More than ten minutes later, the brain of No. 5 was completely separated, but it was not until this time that Chen Chen discovered that the brain of this mouse was not well recovered.

  Because of the large number of neuron deaths caused by Alzheimer's, many connective tissue masses are produced in the area where these nerve cells die. These tissue masses occupy the original space of the brain and make the brain unable to restore its previous state.

"Pity."

  Chen Chen shook his head and soaked these brains into a solution filled with formalin.

  In the past three months, Chen Chen has used cloning as usual to clone this group of mice. At the same time, in these mouse models that also have Alzheimer's disease, a combined treatment method has been used.

  1. Use the gene overexpression method of to1 protein to enhance the brain's resistance to inflammation and gradually eliminate inflammation.

  2, use nezuab antibody developed by Eli Lilly to remove aβ protein and amyloid deposits in the brain.

  Although this drug has failed several clinical trials and proved to be unable to treat Alzheimer’s disease, its ability to clear aβ protein is still worthy of recognition.

  3. By injecting neural stem cells extracted from cloned embryos, at the same time using cytokine means to activate g2 resting stem cells that originally exist in the brain to stimulate the brain to heal itself.

  There is one last item, that is, in the early stage of Alzheimer’s disease, the microglia are activated first to actively engulf abnormally deposited proteins.

  But if Alzheimer's disease has entered the middle or even late stage, the opposite method is used to inhibit the activation of microglia until the nezuab antibody is used to remove most of the aβ deposits before microglia activation.

This is the method Chen Chen adopted. Through the treatment of inflammation and neural stem cell transplantation, coupled with the intervention of the brain’s own immune system, this compound method can completely suppress Alzheimer’s disease in the early and mid-term. It can't get worse and even get better.

  In fact, the actual medical world does not fail to achieve Chen Chen's effect. The only limitation is still cloning. In addition to this limitation, cost is also a factor restricting this treatment.

  After all, with this set of treatment plans alone, the cost is sky-high. If it is used in business, a course of treatment will cost millions of dollars.

  As for the steric hindrance caused by the death of a large number of neurons and the connective tissue occupying the brain, Chen Chen is helpless. Perhaps it is a good way to remove these connective tissues through craniotomy.

  As for the nzt-48 side, due to lack of time and no actual progress, Chen Chen also stopped the experiment.

  Since the nzt-48 experiment was stopped, Chen Chen started beckoning his assistant and assigned some less important tasks. This was how quickly the results of these experiments were obtained.

  Now that the experiment has produced results, Chen Chen no longer hesitates, and directly asks his assistant to send in the old chimpanzee that he had prepared before.

The scientific community has long discovered that chimpanzees can also suffer from Alzheimer's disease, which is the same as that of humans. So before the experiment on mice was completed, they asked their assistants to make Alzheimer's disease models of chimpanzees and clone these chimpanzees. Up.

  This can also save a lot of time.

Not only that, Chen Chen also asked the team to protect his parents in Zhongzhou District to separate one person, go to Shangdu to secretly extract the somatic cells of Professor Wang Xi, and then bring them back to clone Professor Wang Xi. After a few months, Professor Wang Xi really When I came to the research center, I could use the cloned neural stem cells immediately.

  It is a kind of reward to Professor Wang Xi for such exhaustion.

   Thinking of this, Chen Chen was just about to carry out the next experiment when suddenly the phone rang.

  Chen Chen frowned, picked up the phone and took a look, only to realize that it was the call from the screenwriter responsible for the new movie.

  Leaving the laboratory to the assistant, Chen Chen walked out of the laboratory and answered the phone.

  "Have you revised it? I see. I'll check it later."

  It turned out that the screenwriter had once again revised the script according to Chen Chen's requirements and brought it to Chen Chen for review.

  This is the task Chen Chen entrusted to the Edwards family.

   Came to his office, no need to order, Xiao X has opened the mailbox and projected the script sent by the other party on the wall.

  Chen Chen spent a few minutes reading the entire script, then reluctantly nodded.

  The story background of the script is set 3 years after reality. This is what Chen Chen requested. After all, the USB flash drive only accepts movies close to the reality structure, and it is safer to set it directly into the reality background.

The main line of the story is a little-known pharmaceutical company in North America. A researcher named Alexander suddenly discovered a small chemical molecule that can completely inhibit Alzheimer's disease~lightnovelpub.net~ This small molecule can not only prevent tau tangles and prevent aβ deposition, but also eliminate inflammation and completely end all symptoms of Alzheimer's disease.

  This drug is the core of the story.

  The plot is an old-fashioned story about an unknown black force who got the news from nowhere. In order to obtain a sample of the drug, he began to kidnap colleagues around the protagonist. After discovering the situation, the protagonist quickly ran away with the drug and was chased and killed.

  This script has been passed by Chen Chen several times before. In desperation, the screenwriter removed some unreasonable parts of technology and logic in the film. Although these parts are very dramatic, they are also very selling points.

  But this time, it almost met Chen Chen's expectations.

It's a pity that Chen Chen didn't expect that the speed of Hollywood was so slow. It took two months from script writing to revision, and it was impossible to rush out the movie no matter how quickly it was left for one month.

  Fortunately, Chen Chen has found a treatment to suppress Alzheimer's disease. As long as it can be successful in chimpanzees, Chen Chen can enter clinical trials.

   Thinking of this, Chen Chen as the investor replied with a "pass".

  In this way, Hollywood movies can be officially launched.