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"We already know that the structure of the g protein-coupled receptor is a transmembrane structure composed of 7 a helices. Not only that, some of its receptors also contain an extracellular n-terminal or intracellular c-terminal structure. This makes the structure of the g protein-coupled receptor extremely complicated."

Yang Rui took the microphone and talked about his point of view in a slow pace.

Below the podium, nearly 300 scholars were seated in a dense cluster, and corresponding academic media were listed.

This was originally just a project application meeting for the 863 Program. Somehow, the scale increased from 9 judges to nearly 300.

In fact, Yang Rui knows what's going on. This is an application for the g protein-coupled receptor project. If scholars in related fields are not curious, then the Chinese academia will have collapsed.

If you want to give a metaphor that conforms to popular habits, in China in 1986, to apply for the "g protein coupled receptor" project is like the space agency holding a project review meeting, and the project reviewed is the "Sirius Landing and Colonization Project". ".

Of course, everyone knows that Sirius’s landing and colonization cannot be accomplished overnight, or even impossible at all. However, since the applicant is the well-known "Yang Rui", then, even if it is to know what the future will look like 300 years from now. , Everyone is still willing to come and listen.

In fact, it is hard to say who is difficult and who is easy to study thoroughly what is going on with g-protein coupled receptors. This difficulty is related to colonization outside the solar system.

Even if Yang Rui took a small step, it was enough to make everyone listen.

However, Yang Rui didn't just want to take a small step.

He took the microphone and looked at the people below. These may represent the highest level of people in the protein field in China, and said with a clear voice: "Some structural biology studies have already obtained lower-resolution structures, let us see g The general direction of protein-coupled receptors, but these structures are too rough and there are too many problems to explain."

"I want to explain some of the problems." Yang Rui was not arrogant, nor did he mean to be humble, and said: "The questions I want to explain are as follows. First, why is the same seven-pass transmembrane structure? How can hundreds of different molecules in the body family specifically recognize substrate molecules as small as photons and as large as proteins, and these substrate molecules, whether in shape, nature, or volume, have huge differences."

"Second, I want to know the signal transmission problem of the receptor."

If you say that when Yang Rui said the first point, the scholars in the audience could still watch his performance with a smile, but when they heard the second point, everyone was already talking about it.

Because Yang Rui put forward two different questions and different directions.

To study the structure, or to study the signal, these are two links and two levels of difficulty.

Those who do structure will not run to make signals, and those who do signal will not run to make structures. Although they are all in the field of protein, they basically belong to two branches. Moreover, the two are difficult to compare with each other. Why? Want to do it at the same time?

Including 9 senior scholars who are judges, all of them are now frowning and looking at Yang Rui.

Yang Rui just missed it.

He certainly knows that the two problems of structure and signal transmission are very difficult.

In fact, as long as you make any one, it is possible to win the Nobel Prize.

The combination of the two constitutes a complete Nobel Prize—according to the "Nobel Prize Foundation Regulations", the Nobel Prize can be awarded to three individuals at the same time. In the fourth section of the "Statutes", it stipulates this: "Award can be scored for two jobs, and each job must be worthy of award. If two or three people have completed a worthy job together, the award should be awarded to them at the same time. But in either case, No one award can be awarded to more than three people at the same time."

Before the 1980s, or earlier, before the 1960s, the Nobel Prize was often awarded to one or two people. However, with the development of science and technology, the importance of the Nobel Prize has increased. It is normal for three people to award awards.

For example, what Yang Rui is doing now, the structure and signal of g protein-coupled receptors should have been shared by American scientists Lefkowitz and Kebilka.

But that was in 2012.

Since Yang Rui chose the pre-research mode, naturally he didn't want to play any more sharing mode.

In addition, the structure and signal can be made together to give a general understanding of the g protein-coupled receptor, which is indispensable.

If Yang Rui only did one of them, he would still be able to win the Nobel Prize.

G-protein coupled receptors are different from other fields, because this field is too difficult, so accumulation is necessary, but sometimes it depends on luck and inspiration.

Therefore, the Nobel Prize in 12 years, the Nobel Prize in 2002, or even the Nobel Prize in 1992 are not too far away, at least for Yang Rui, it is not an insurmountable distance.

Of course, the odds of this thing winning a prize are also great.

The normal Nobel Prize, waiting for ten or eight years, or twenty years to win the prize, is considered normal, unfortunately, it’s normal to wait until people die and the lights are off before the award is given. The faster one is pcr. Usually Wait a few years for a chance.

However, g protein-coupled receptors are more powerful. As far as the 12-year version is concerned, the results were obtained in 11 years, and the awards were awarded in 12 years.

No way, this thing is too benevolent.

Of course, this is not to say that if you make a g protein-coupled receptor, you will definitely be able to win the award the next year. It can only be said that it adds another weight.

The Nobel Prize is the same as the God outfit.

You know that bosses will pretend to be magical. The ultimate boss has a high probability, a big boss has a small probability, and a small boss has a chance. Therefore, the correct method of brushing is not to swipe an ultimate boss and then look at the face, but to pile up bosses and build a mountain of dead bodies. That **** pretend is going to fall into your hands after all.

Yang Rui is not very confident in luck, but he is quite confident in his ability to brush up the boss.

After speaking a few more points, Yang Rui returned the microphone to today's host and recommender of the project, Academician Zhu.

"Thank you, Comrade Yang Rui, next, please ask questions from the judges who have questions." Academician Zhu's voice was lazy, and his eyes rolled curiously on the faces of a group of people.

He wanted to know how many people really understood.

The judges sat up straight together, and several people also made noises in about the same time.

"You go first."

"You ask first."

"After you."

Several people kept giving back and forth.

Afterwards, Professor Qian sitting in the middle of the judges said: "Yang Rui, your plan looks good, is it a bit too ambitious?"

"It is indeed a grand plan, but I am confident that I can complete this plan through the ion channel laboratory of Peking University and prove that the ion channel laboratory is a world-class laboratory."

Wow.

The scholars in the stands began to discuss again.

Yang Rui just nodded slightly, looked at Academician Zhu, and then turned around, saying: "The Ion Channel Laboratory of Peking University has raised 6 million U.S. dollars and 2 million yuan in funding. This time, he applied for 3 million yuan to the 863 Program. The total funding is also to enhance our strength..."

Yang Rui was sharp and sharp, and didn't mean to be humble anymore.

Standing on the king's path and rushing forward~lightnovelpub.net~ Everyone will see you, and you can’t hide even if you cower and hide.

And the edge of attacking with 6 million US dollars is really something that many people can't resist.

Professor Qian couldn't help but sit down quietly.

If he asks questions now, he will only take it upon himself.

"Next, is there any other question?" Academician Zhu asked softly.

The nine judges shook their heads together.

"Then vote now. Those who agree to pass the project and the applied amount, please raise their hands.

The nine paws were raised together.

"Okay, I announce that the first project of the National High-Tech Research and Development Program, the structure and signal of g protein-coupled receptors, has been officially passed. The person in charge is Yang Rui of Peking University..." Before Academician Zhu's words fell, the applause was soft Rang.

The louder the louder, the louder the louder.