Chapter 728 New Ideas

  After eating, Guo Xiang returned to the laboratory and received a call from Song Tingshen.

   "Ms. Song?" Guo Xiang called.

   "Guo Xiang, how is your HIV drug progress?" Song Tingshen asked.

   "No progress." Guo Xiang shook his head, tried so many kinds of drugs, but the effect was not obvious. It may be the wrong combination or the wrong dosage.

"The last time the patient with liver cancer had an AIDS outbreak. It may be that the body's resistance to the operation became weaker, and the immune system would not work as soon as it was attacked. Now he has symptoms of persistent fever, enlarged lymph nodes, and a red skin rash. "Song Tingshen said.

   "That is the disease." Guo Xiang frowned, "You can let him take the medicine first. Although our joint medicine has not yet been released, ordinary medicine can still be taken first."

   "Then we have nothing to do. There is no department for this disease in our country, and there is no medicine. We can only let him return to China for treatment." Song Ting sighed deeply.

  Guo Xiang nodded. There is indeed no way. Although they have medicine in the laboratory, they are also used for experiments. They are not a place to see a doctor, and there is no other treatment equipment. There is no way to help him.

  "Then let him go back to China, there is no other way." Guo Xiang said, "I also want to speed up the progress here and do it earlier."

  Song Tingshen hung up the phone and could only tell the truth to the patient. There was really no way to treat him. It would be useless for him to stay in the hospital.

  The patient also understands that after going through the discharge procedures, he has been living with liver cancer for more than a month and was also when he was discharged. However, he is now in such a poor health and is likely to relapse, but there is no way. This is something that no one can control.

  Guo Xiang told Li Yuanhang about the patient, and he nodded, “We can only control it with medicine first, and we will talk about it when there is resistance. We will also speed up the progress.”

  Guo Xiang nodded, looked at the data in the computer, and took the new set of formula medicines to the mice.

  Mixed the medicine in the rat feed and was about to feed it to the mice. Guo Xiang noticed that some of the mice that had already contracted AIDS were still very energetic, and some of them were mentally depressed.

  She suddenly realized a problem. Western medicines are generally relatively fixed, but they will be distinguished according to the age of the person.

  For example, every time an adult takes three capsules, the child will halve it and take one and a half capsules. This is generally the rule.

  The experimental mice are small and usually recalculate the dose by weight.

  Just like some infant medications, the weight is calculated based on the weight. How many milliliters should be taken within a few kilograms, and how many milliliters should be taken over a few kilograms.

  But there is no classification according to the severity of the illness.

  If it is possible to do this, it is Chinese medicine. Chinese medicine usually diagnoses by touching the pulse, and prescribes medicine according to the difference of each body's constitution and different conditions.

  So each patient may have different prescriptions and dosages. This is one of the reasons why Chinese medicine cannot be promoted like Western medicine.

  However, the severity of the AIDS situation is obvious. Some may not have the disease but just carry it, some are severe, and various symptoms appear, and some are mild, so can I still use the same medicine and the same dose?

Is it necessary to divide people according to their physique and condition like traditional Chinese medicine?

  Guo Xiang suddenly felt that his idea was right, because the HIV virus attacks the human immune system.

  Maybe most people have only a very vague concept of the immune system, and they don’t know what it is.

  In fact, the human body is a very sophisticated system with its own defense forces to deal with foreign invaders.

  And these defense forces are numerous immune cells. For example, lymphocytes are immune cells that fight infection and tumors. The most important thing here are Th cells containing CD4 molecules and Tc cells containing CD8 molecules. In other words, T cells are the guardians of disease resistance.

  And CD4 cells are equivalent to sentinels, playing the role of "information", CD8 cells are combat troops, have the effect of killing infected cells and cancer cells.

  When HIV enters the human body, it infects surface CD4 cells, so that CD8 cells cannot kill infected cells and cancer cells, leading to opportunistic infections and cancer.

  So once a person is infected with the HIV virus, CD4 cells will appear progressive or irregular decline, which indicates that the immune system is severely damaged.

  Generally, the number of CD4 cells in normal people is 500~1600 per cubic millimeter, which can be detected by blood sampling.

  So the CD4 cells of each of these mice may be different, and the drugs used and the amount of drugs should also be different.

  Guo Xiang suddenly realized that they might have done useless work in the previous month.

  She immediately called Li Yuanhang over and said her thoughts.

  Li Yuanhang listened very carefully, and nodded as he listened, "It is very likely that this is the case."

  "Did you not consider this when you were in the United States?" Guo Xiang couldn't help the question. They had been studying for so many years.

   "I entered the research room relatively late, and CD4 cells were also tested there, but at that time they were all used as a single drug. Now I have not thought about this in combination." Li Yuanhang said.

  "I think our previous thinking was wrong. We should use the medicine according to the number of CD4 cells in each mouse, so that it will be effective." Guo Xiang said.

  Li Yuanhang nodded, "Yes, we have tried so many medicines before, and it is impossible to have no effect. It should be for this reason, there is no symptom!"

"Then we will measure the CD4 cells of each mouse immediately, and then adjust the medication and dosage." Guo Xiang said decisively, "The number of CD4 cells in normal people is 500-1600. Setting more than 500 is a safe value. It may be measured. Is positive, but within a safe range, he has not yet developed a disease, and he is still a carrier."

"The patients between 0 and 200 are already very serious, with complications, and they are severely ill; patients between 200 and 500 are mild patients, although they are onset but the symptoms are not serious." Guo Xiang continued, picking up the previous notebook, "then Our medications are also divided into groups, one group is tenofovir, zidovudine, and lamivudine, and the other group is efavirenz, nevirapine, and klitsch, and the medications are differentiated for different stages of symptoms."

   "Okay, we will re-test immediately." Li Yuanhang nodded, and at the same time he admired Guo Xiang very much. He didn't expect this.

  The two began to draw blood from the mice and put them in a flow cytometer for testing. These equipments were all bought from the United States.

   Then give each mouse a number, indicate the number of their CD4 cells, and then use different drugs and doses.

  After finishing these, both of them are a little excited, and have a hunch that they might succeed this time.

  After all the work was done, the two of them sorted out the laboratory, and the consoles were sterilized, before leaving the laboratory, they took off their protective clothing and put on white coats.

  Guo Xiang suddenly found Gu Zhennan standing outside the office window.

  She opened the window, "Why are you here?"

   "What time is it? You don't look at the time, I thought something happened to you." Gu Zhennan complained a little bit.

  Guo Xiang only noticed that it was dark outside, and when he looked at the clock on the wall, it was already past eight o’clock. He was surprised, “It’s so late?”

   "We forgot the time as soon as we did the experiment." Li Yuanhang smiled and looked at Gu Zhennan. This should be Teacher Guo's lover, right?

There is a Japanese anime called "Working Cells" which talks about the working state of various cells in the human body. It is an anthropomorphic technique. The cells are drawn as human beings. There are cute red blood cells, cute platelet cells, and killer Ts. Cells, very interesting, friends who are interested can take a look.

  　　

  　

  (End of this chapter)