Silicon Valley

v2 Chapter 453: Y chromosome

Through data comparison, Henry found that his genes are very different from those of ordinary people. Although there are great differences between the genes of each person, the length of Henry's pair of XY **** chromosomes, especially the Y chromosome, is longer than that of ordinary people's Y chromosomes. In other words, Henry's Y chromosome has more genes than ordinary people! ! !

This is really abnormal!

"Mr. Williams, when we first saw it, we were shocked and puzzled too!"

The speaker is Professor Thomson, aged 60 or 70, who is responsible for gene sequencing. "After careful research, we found that there are 10 more types of genes on your Y chromosome than ordinary people. Of course, there may be more. We have no genes found. You know, the Y chromosome is the most complex structure of all chromosomes, and it has too many repetitive genes that are not easy to detect!"

Henry nodded when he heard the words, because the Y chromosome was indeed the most difficult to detect. The test was only successful in 2010 in the previous life. Because there are too many duplicate genes or useless genes in the Y chromosome, and constitute a very complicated palindrome structure. It takes a long time for people to research and find out this kind of palindrome structure.

Palindrome structure refers to the sequence of the same structure and opposite direction contained in double-stranded DNA. For example, one is "ABCDE" and the other is "EDCBA". Although it may seem simple, it is not easy to find the regularity among the complex Y chromosomes. The Y chromosome is complex like a mirror, and researchers stand among countless mirrors looking for answers-the types and numbers of genes. This workload is simply staggering, and Gene Umbrella has spent a lot of manpower and material resources to complete the general inspection of the Y chromosome.

"Mr. Williams, the mutation in your brain is probably related to a new gene in the Y chromosome! In addition, we also found a strange phenomenon." Professor Thomson said it suddenly stopped, as if Thinking.

After a while, he said: "Mr. Williams, do you remember when you fainted because of brain mutation?"

Henry nodded and said, "Remember."

"Well... Dr. Rothman gave you a test at that time and found that your cerebral cortex secretes a mysterious T substance, which strongly promotes the active growth of brain cells. A conclusion reached at that time is that brain cells grow rapidly, or there may be It may cause the life span of brain cells to be too short!"

"Yes!" Henry nodded and couldn't help asking, "What's the matter, Professor Thomson, have you made a new discovery?"

"Yes!" Professor Thomson nodded, "Through several years of tracking and testing, we have found that your brain cells have not shown signs of aging, but have become more and more energetic, with lush and powerful vitality! Therefore, I speculate that there may be other reasons why your brain cells become so powerful! As for this reason, it must be related to your genes!"

Henry was overjoyed when he heard this. Before this, he always felt that a stone was pressed down, but now he finally put it down.

However, it didn't take long for Henry to be happy.

Professor Thomson poured cold water down and said: "Mr. Williams, because your XY chromosomes are different from ordinary people, I am afraid that you will have great difficulties in fertility!"

"What do you say?!" Henry couldn't help frowning.

"According to our research, the Y chromosome and the X chromosome are not a match made in heaven. On the contrary, they are more like a pair of rivals who do not give in to each other!"

Professor Thomson said slowly, “The X chromosome has 1438 genes, while the Y chromosome has only 45 genes. 300 million years ago, the original ancestors of **** chromosomes X and Y were no different from ordinary chromosomes. DNA duplication, chromosome union and homologous gene recombination and exchange were carried out normally. But one day, the Y chromosome suddenly mutated, and a gene called SOX3 on one of the original **** chromosomes mutated and became The gene named SRY. According to our research, the SRY gene should be the key gene for male sex! Since then, gender differences have begun to form."

"In order to further strengthen their respective genders, the X and Y chromosomes have evolved more genes that are conducive to gender prominence, and finally formed a genetic base camp that maintains gender characteristics. The genetic members in such base camps are all against each other's members. Unfriendly. Genes on the Y chromosome that are good for males are often bad for females; on the contrary, genes on the X chromosome that are good for females are always trying to destroy the characteristics of males. Therefore, when the two are combined, they will attack each other. But in the course of years of confrontation and evolution, the Y chromosome has reached a tacit cooperation with the X chromosome, so that it can continue to reproduce offspring. Now, Mr. Williams, your problem is that your Y chromosome is more than the Y chromosome of ordinary people. With 10 genes, this difference makes it difficult to ensure that the woman’s X chromosome and your Y chromosome are combined! At the same time, your body’s X chromosome has also undergone many changes, and the problem is not small..."

Henry frowned. This situation is indeed, as Professor Thomson said, there is a big problem in fertility.

"Mr. Williams, don't worry too much. I believe that we will think of a solution one day!" Professor Thomson comforted, "Furthermore, your XY **** chromosome may also have a certain chance of competing with Mrs. Williams. The X chromosomes of the people are combined together, the probability is only a little lower than that of ordinary people...

"Thank you for your comfort, Professor Thomson. We will not talk about this question for the time being. I believe that as long as biotechnology is improved, there is no problem that cannot be solved." Henry paused and asked in a deep voice after he finished speaking. "Professor Thomson, how is the research on the new generation of gene sequencing technology?"

"The progress is very fast, and it will be completed in one or two months!" Professor Thomson replied.

"Yeah!" Henry nodded in satisfaction.

The traditional way of gene detection is to use optical sequencing technology. Four different genes are labeled with different colors of fluorescence, and then a laser light source is used to capture the fluorescence signal to obtain the sequence information of the gene to be tested. This method is reliable but expensive. The price of a sequencing instrument is between 500,000 and 750,000 U.S. dollars, and the cost of a test is as high as 5,000 to 10,000 U.S. dollars. It is also due to the fact that the Gene Umbrella Company is very rich and can produce on its own to reduce costs. This has led to a large number of instruments for gene sequencing. And all the institutions or companies that conduct gene sequencing research in the world, the instruments they use all add up to not as many as the gene umbrella company.

The latest genetic testing method is ~lightnovelpub.net~ which uses a chip instead of traditional laser lenses, fluorescent dyes, etc. The chip is a sequencer. Through the semiconductor sensor, the instrument directly detects the ion current generated during DNA replication. When reagents enter the chip through the integrated fluid pathway, the reaction holes densely packed on the chip immediately become millions of micro-reaction systems.

This combination of technologies enables researchers to obtain genetic information in just 2 hours. Using traditional optical sequencing technology, it takes weeks or even months to get results. At the same time, the cost of a test has also been reduced to a minimum of 1,000 US dollars.

Henry thought for a while, and said: "Since the next generation of gene sequencing technology is about to be developed, it is time to update it! Professor Thomson, let people dispose of our instruments cheaply as soon as possible!"

"Okay!" Professor Thomson nodded.

"Next, first sequence all the genes of the mutants of the Gene Umbrella X experiment. I want to get their powerful mutant genes!!!" Henry's eyes flashed a little...

"Understand, I will do it right away!!!"

(To be continued.)